Some became seriously ill and 74 people died, the CDC said. It said 396 — 7% — of those who got infected after they were vaccinated required hospitalization.

It’s the first indication from CDC of how effective the vaccine is in real life — and the first indication the vaccines do not protect completely against severe disease and death.

“So far, about 5,800 breakthrough cases have been reported to CDC. To date, no unexpected patterns have been identified in case demographics or vaccine characteristics,” the CDC told CNN via email.

So far, about 77 million people in the US are fully vaccinated against coronavirus, according to a CNN analysis of CDC data. The CDC’s reports on breakthrough cases will lag day-to-day reports of vaccines given, so may not reflect the most current events.

It’s not unexpected to see breakthrough cases. The vaccines are not 100% effective in preventing infections and as tens of millions of people are vaccinated, more and more such cases will be reported.

Pfizer/BioNTech’s vaccine was 95% effective in preventing symptomatic disease in clinical trials, and earlier this month the companies said real-life data in the US shows the vaccine is more than 91% effective against disease with any symptoms for six months.

Ongoing trial shows Pfizer Covid-19 vaccine remains highly effective after six months

Moderna’s vaccine was 94% effective in preventing symptomatic illness in trials, and 90% effective in real life use. Johnson & Johnson’s vaccine was 66% overall globally in trials, and 72% effective at preventing disease in the US.

CDC will be looking for clues about who is most prone to become infected despite having been vaccinated.

“Vaccine breakthrough infections were reported among all people of all ages eligible for vaccination. However, a little over 40% of the infections were in people 60 or more years of age,” the CDC said.

Most, 65%, were female and 29% of the so-called breakthrough infections were asymptomatic. “CDC is monitoring reported cases for clustering by patient demographics, geographic location, time since vaccination, vaccine type or lot number, and SARS-CoV-2 lineage,” the CDC said.

CDC study finds Pfizer, Moderna vaccines are 90% effective after two doses in real-world conditions

Plus, samples from cases will be tested to see how many are caused by variants and if so, which ones.

“CDC has developed a national COVID-19 vaccine breakthrough database where state health department investigators can currently enter, store, and manage data for cases in their jurisdiction,” the CDC said.

“Vaccine breakthrough infections make up a small percentage of people who are fully vaccinated. CDC recommends that all eligible people get a COVID-19 vaccine as soon as one is available to them. CDC also continues to recommend people who have been fully vaccinated should keep taking precautions in public places, like wearing a mask, staying at least six feet apart from others, avoiding crowds and poorly ventilated spaces, and washing their hands often.”

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